Preprints

    Saranne J. Mitchell, Carlos Pardo-Pastor, Thomas A. Zangle, Jody Rosenblatt, “Voltage-dependent volume regulation controls epithelial cell extrusion and morphology,” bioRxiv, doi: 10.1101/2023.03.13.532421.
    Yuntian Zhang, Rachel L Belote, Marcus A Urquijo, Maike M. K. Hansen, Miroslav Hejna, Tarek E. Moustafa, Tong Liu, Devin Lange, Fatemeh Vand-Rajabpour, Matthew Chang, Brian K. Lohman, Chris Stubben, Xiaoyang Zhang, Leor S. Weinberger, Matthew W. VanBrocklin, Douglas Grossman, Alexander Lex, Rajan Kulkarni, Thomas A. Zangle, and Robert L. Judson-Torres, “Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes,” bioRxiv, doi: 10.1101/2020.08.26.269126.

Peer Reviewed Publications

  1. Moustafa, T.E., Belote, R.L., Polanco, E.R., Judson-Torres, R.L., and Zangle, T.A., “Quadrant darkfield (QDF) for label-free imaging of intracellular puncta,” accepted at Journal of Biomedical Optics, 2024. preprint doi: 10.1101/2024.08.05.606686.
    2. QDF
  2. Eric A. Smith, Rachel L. Belote, Nelly M. Cruz, Tarek E. Moustafa, Carly A. Becker, Amanda Jiang, Shukran Alizada, Tsz Yin Chan, Tori A. Seasor, Michael Balatico, Emilio Cortes-Sanchez, David H. Lum, John R. Hyngstrom, Hanlin Zeng, Dekker C. Deacon, Allie H. Grossmann, Richard M. White, Thomas A. Zangle, and Robert L. Judson-Torres, “Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment,” accepted at Journal of Experimental & Clinical Cancer Research, 2024. preprint doi: 10.1101/2024.06.15.599116.

  3. Alyssa L. Harpring, Soorya Pradeep, and Thomas A. Zangle, “Comparison of automated and manual intracellular particle tracking using quantitative phase imaging,” Journal of the Optical Society of America A, 2024, 41(11). C49-C54. doi: 10.1364/JOSAA.534154. (link).

    4. Particle Tracking

  4. Jingzhou Zhang, Justin Griffin, Koushik Roy, Alexander Hoffmann, and Thomas A Zangle, “Tracking of Lineage Mass via Quantitative Phase Imaging and Confinement in Low Refractive Index Microwells,” Lab on a Chip, 2024, 24. 4440-4449. doi: 10.1039/D4LC00389F.

    5. Lineage Tracking

  5. Devin Lange, Robert Judson-Torres, Thomas A. Zangle, and Alexander Lex, “Aardvark: Composite Visualizations of Trees, Time-Series, and Images,” IEEE Transactions on Visualization and Computer Graphics, 2024. doi: 10.1109/tvcg.2024.3456193.

  6. Soorya Pradeep and Thomas A. Zangle, “LVING Reveals the Intracellular Structure of Cell Growth,” Scientific Reports, 2024, 14. 8544. doi: 10.1038/s41598-024-58992-x. (link).

    7. LVING

  7. Chelsea U. Kidwell, Joseph R. Casalini, Soorya Pradeep, Sandra D. Scherer, Daniel Greiner, Jarrod S. Johnson, Gregory S. Olson, Jared Rutter, Alana L. Welm, Thomas A. Zangle, and Minna Roh-Johnson, “Transferred mitochondria accumulate reactive oxygen species, promoting proliferation,” eLife 2023, 12. e85494. doi: 10.7554/eLife.85494.

  8. Tarek E. Moustafa, Edward R. Polanco, Rachel L Belote, Robert L Judson-Torres, and Thomas A. Zangle, “Fabrication and validation of an LED array microscope for multimodal, quantitative imaging,” HardwareX, 2023, 13. e00399. (link)

    9. HardwareX


  9. Edward R. Polanco, Tarek E. Moustafa, Andrew Butterfield, Sandra D. Scherer, Emilio Cortes-Sanchez, Tyler Bodily, Benjamin T. Spike, Bryan E. Welm, Philip S. Bernard, and Thomas A. Zangle, “Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer,” Communications Biology, 2022, 5. 794. (link)

    10. Multiparametric QPI

  10. Thang L. Nguyen, Soorya Pradeep, Robert L. Judson-Torres, Jason Reed, Michael A. Teitell, and Thomas A. Zangle, “Quantitative Phase Imaging: Recent Advances and Expanding Potential in Biomedicine,” ACS Nano, 2022, 16. 11516-11544. (link)

    11. QPI Review


  11. Soorya Pradeep and Thomas A. Zangle, “Quantitative phase velocimetry for label-free measurement of intracellular mass transport velocity,” Scientific Reports, 2022, 12. 6074. (link)

    12. QPV

  12. Devin Lange, Edward R. Polanco, Robert Judson-Torres, Thomas A. Zangle, and Alexander Lex, “Loon: Using exemplars to visualize large-scale microscopy data,” IEEE Transactions on Visualization and Computer Graphics (VIS) 2021. doi: 10.1109/TVCG.2021.3114766. (link) (pdf)

  13. Edward R. Polanco, Justin Griffin, and Thomas A. Zangle, “Fabrication and bonding of refractive index matched microfluidics for precise measurements of cell mass,” Polymers 2021, 13. 496. (pdf)

    14. NOA1348

  14. Soorya Pradeep, Tasmia Tasnim, Huanan Zhang, and Thomas A. Zangle, “Simultaneous measurement of neurite and neural body mass accumulation via quantitative phase imaging,” Analyst 2021, 146. 1361-1368. (link)

    15. Neuron QPI

  15. Thang L. Nguyen, Edward R. Polanco, Alexander N. Patananan, Thomas A. Zangle*, and Michael A. Teitell*, “Cell viscoelasticity is linked to fluctuations in cell biomass distributions,” Scientific Reports 2020, 10. 7403. *co-corresponding (link)

    16. QPR

  16. Dian Huang, Irena J. Roy, Graeme F. Murray, Jason Reed, Thomas A. Zangle*, and Michael A. Teitell*, “Identifying fates of cancer cells exposed to mitotic inhibitors by quantitative phase imaging,” Analyst 2019, 145. 97-106. *co-corresponding (link)

  17. Lynnea R. Waters, Fasih M. Ahsan, Johanna ten Hoeve, Jason S. Hong, Diane N.H. Kim, Aspram Minasyan, Daniel Braas, Thomas G. Graeber, Thomas A. Zangle, and Michael A. Teitell, “Ampk Regulates IgD Expression but not Energy Stress with B Cell Activation,” Scientific Reports 2019, 9. 8176. (link)

  18. Edward R. Polanco, Nicholas Western, and Thomas A. Zangle, “Fabrication of refractive-index-matched devices for biomedical microfluidics,” Journal of Visualized Experiments (JoVE) 2018, 139. e58296. (link) (pdf) (video)

    19. MY133 protocol

  19. Simon Mitchell, Koushik Roy, Thomas A. Zangle, and Alexander Hoffmann, “Non-genetic origins of cell-to-cell variability in B-lymphocyte proliferation,” Proceedings of the National Academy of Sciences, USA 2018, 115. E2888-E2897. (link)

  20. Dian Huang, Kevin A. Leslie, Daniel Guest, Olga Yeshcheulova, Irena J. Roy, Marco Piva, Gatien Moriceau, Thomas A. Zangle, Roger S. Lo, Michael A. Teitell, and Jason Reed, “High Speed Live Cell Interferometry: A New Method for Rapidly Quantifying Tumor Drug Resistance and Heterogeneity,” Analytical Chemistry 2018, 90. 3299-3306. (link)


  21. Diane N.H. Kim, Kevin T. Kim, Carolyn Kim, Michael A. Teitell, and Thomas A. Zangle, “Soft lithography fabrication of index-matched microfluidic devices for reducing artifacts in fluorescence and quantitative phase imaging,” Microfluidics and Nanofluidics 2018, 22. 1-11. (link)

    22. Low n micro
  22. Diane N.H. Kim, Michael A. Teitell, Jason Reed and Thomas A. Zangle, “Hybrid random walk-linear discriminant analysis method for unwrapping quantitative phase microscopy images of biological samples,” Journal of Biomedical Optics 2015, 20. 111211. (link) (pdf)
    23. Phase Unwrapping
  23. Thomas A. Zangle* and Michael A. Teitell,* “Live cell mass profiling: An emerging approach in quantitative biophysics,” Nature Methods 2014, 11. 1221-1228. *co-corresponding (link) (pdf)
    24. NMeth Review


  24. Thomas A. Zangle, Michael A. Teitell and Jason Reed, “Live cell interferometry quantifies dynamics of biomass partitioning during cytokinesis,” PLOS ONE 2014, 9. e115726. (link)
    25. Cell Division

  25. Silvia Senese, Yu-Chen Lo, Dian Huang, Thomas A. Zangle, Ankur A. Gholkar, Lidia Robert, Blanca Homet, Antoni Ribas, Matthew K. Summers, Michael A. Teitell, Robert Damoiseaux and Jorge Z. Torres, “Chemical dissection of the cell cycle: Probes for cell biology and anti-cancer drug development,” Cell Death & Disease 2014, 5. e1462. (link)


  26. Thomas A. Zangle, Jennifer Chun, Jin Zhang, Jason Reed and Michael A. Teitell, “Quantification of biomass and cell motion in human pluripotent stem cell colonies,” Biophysical Journal 2013, 105. 593-601. (pdf) (commentary)
    27. hPSC


  27. Thomas A. Zangle, Daina Burnes, Colleen Mathis, Owen N. Witte and Michael A. Teitell, “Quantifying biomass changes of single CD8+ T cells during antigen specific cytotoxicity,” PLOS ONE 2013, 8. e68916. (link)
    28. T Cell


  28. Jennifer Chun, Thomas A. Zangle, Theodora Kolarova, Richard S. Finn, Michael A. Teitell and Jason Reed, “Rapidly quantifying drug sensitivity of dispersed and clumped breast cancer cells by mass profiling,” Analyst 2012, 137. 5495-5498. (pdf)

  29. Jason Reed, Jennifer Chun, Thomas A. Zangle, Sheraz Kalim, Jason S. Hong, Sarah E. Pefley, Xin Zheng, James K. Gimzewski and Michael A. Teitell, “Rapid, massively parallel single-cell drug response measurements via live cell interferometry,” Biophysical Journal 2011, 101. 1025-1031. (pdf)
    30. Drug Response

  30. Matthew E. Suss, Ali Mani, Thomas A. Zangle and Juan G. Santiago, “Electroosmotic pump performance is affected by concentration polarizations of both electrodes and pump,” Sensors and Actuators A: Physical 2011, 165. 310-315. (link)

  31. Thomas A. Zangle, Ali Mani and Juan G. Santiago, “Effects of constant voltage on time evolution of propagating concentration polarization,” Analytical Chemistry 2010, 82. 3114-3117. (pdf)
    32. Constant Voltage CP
  32. Thomas A. Zangle, Ali Mani and Juan G. Santiago, “Theory and experiments of concentration polarization and ion focusing at microchannel and nanochannel interfaces,” Chemical Society Reviews 2010, 39. 1014-1035. (pdf)
    33. CP Review

  33. Daniel G. Strickland, Matthew E. Suss, Thomas A. Zangle and Juan G. Santiago, “Evidence shows concentration polarization and its propagation can be key factors determining electroosmotic pump performance,” Sensors and Actuators B 2010, 143. 795-798. (link)

  34. Thomas A. Zangle, Ali Mani and Juan G. Santiago, “On the propagation of concentration polarization from microchannel-nanochannel interfaces. Part II. Numerical and experimental study,” Langmuir 2009, 25. 3909-3916. (pdf) (supp info pdf)
    35. CP Experiments/Theory

  35. Ali Mani, Thomas A. Zangle and Juan G. Santiago, “On the propagation of concentration polarization from microchannel-nanochannel interfaces. Part I. Analytical model and characteristic analysis,” Langmuir 2009, 25. 3898-3908. (pdf)